Prospective (e-diary) vs retrospective (ARIA) measures of severity in allergic rhinoconjunctivitis: an observational compatibility study

Severity assessment in relation to allergen exposure is an essential part of the diagnostic work-up for seasonal allergic rhinoconjunctivits (AR). Regularly recorded patient-reported symptom data may support the physician's decision-making on etiological diagnosis and therapeutic success of a pharmacological treatment or allergen-specific immunotherapy (AIT). Although several mobile applications facilitate the prospective collection of symptom data via e-diaries, severity measures often still rely on retrospective questionnaires and studies on data quality and validation in longitudinal data sets are scarce. In this analysis, we aim to investigate whether and how prospectively acquired measures of disease severity (e-diary) relate to those retrospectively assessed via the Allergic Rhinitis and its Impact on Asthma (ARIA) questionnaire in grass pollen allergic patients.